Manuela G López Selected Research

2- chloro- 5,6- dihydro- 5,6- diacetyldibenzo(b,f)(1,4,5)thiadiazepine

9/2014

ITH12410/SC058: a new neuroprotective compound with potential in the treatment of Alzheimer's disease.

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Manuela G López Research Topics

Disease

22	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2004
19	Neuroblastoma 10/2019 - 01/2004
13	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 04/2009
11	Brain Ischemia (Cerebral Ischemia) 04/2017 - 08/2007
9	Stroke (Strokes) 01/2018 - 04/2009
8	Inflammation (Inflammations) 01/2022 - 08/2013
8	Ischemia 01/2020 - 08/2007
6	Neuroinflammatory Diseases 04/2021 - 01/2015
6	Infarction (Infarctions) 01/2019 - 04/2013
5	Hypoxia (Hypoxemia) 10/2020 - 07/2004
5	Pain (Aches) 01/2019 - 07/2008
4	Tauopathies 01/2022 - 01/2018
3	Reperfusion Injury 06/2013 - 08/2007
2	Major Depressive Disorder (Major Depressive Disorders) 11/2021 - 11/2019
2	Cognitive Dysfunction 01/2021 - 08/2019
2	Nervous System Diseases (Neurological Disorders) 01/2019 - 04/2015
2	Ischemic Stroke 01/2019 - 01/2018
2	Schizophrenia (Dementia Praecox) 05/2015 - 10/2014
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2015 - 01/2014
2	Vascular Diseases (Vascular Disease) 01/2011 - 08/2010
1	Frontotemporal Dementia (Semantic Dementia) 01/2022
1	Body Weight (Weight, Body) 04/2021
1	Iron Overload 01/2021
1	Proteostasis Deficiencies 08/2019
1	Gliosis 01/2019
1	Astrocytoma (Pilocytic Astrocytoma) 01/2018
1	Chronic Disease (Chronic Diseases) 01/2018

Drug/Important Bio-Agent (IBA)

16	Neuroprotective AgentsIBA 01/2020 - 12/2005
10	MelatoninIBA 08/2019 - 05/2009
9	Galantamine (Galanthamine)FDA LinkGeneric 09/2013 - 01/2004
8	CalciumIBA 11/2021 - 10/2008
8	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 05/2011
8	Oxygen (Dioxygen)IBA 01/2020 - 05/2011
8	Cholinergic Agents (Cholinergics)IBA 10/2017 - 12/2007
7	Okadaic AcidIBA 01/2022 - 12/2005
7	AntioxidantsIBA 07/2020 - 05/2009
6	RotenoneIBA 10/2019 - 05/2009
6	Pharmaceutical PreparationsIBA 01/2019 - 10/2006
6	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2019 - 01/2004
6	Tacrine (Cognex)FDA Link 01/2015 - 12/2006
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2012
5	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2018
5	oligomycin AIBA 10/2019 - 07/2010
5	Glutamic Acid (Glutamate)FDA Link 01/2017 - 01/2006
4	LigandsIBA 09/2013 - 05/2009
3	1,4-dihydropyridine (dihydropyridine)IBA 07/2020 - 12/2006
3	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2019 - 10/2014
3	Peptides (Polypeptides)IBA 01/2019 - 01/2004
3	Amyloid (Amyloid Fibrils)IBA 01/2019 - 09/2004
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2016 - 02/2009
3	Amyloid beta-PeptidesIBA 02/2015 - 12/2005
3	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2015 - 12/2005
3	Nicotine FDA Link 10/2014 - 12/2005
3	AcetylcholinesteraseIBA 12/2006 - 01/2004
2	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2022 - 01/2019
2	EnzymesIBA 01/2022 - 08/2008
2	Ligand-Gated Ion ChannelsIBA 11/2021 - 10/2014
2	PNU-282987IBA 04/2021 - 10/2013
2	Phosphotransferases (Kinase)IBA 12/2020 - 07/2020
2	Superoxides (Superoxide)IBA 10/2020 - 01/2017
2	tau Proteins (tau Protein)IBA 07/2020 - 01/2006
2	Caspase 3 (Caspase-3)IBA 08/2019 - 02/2009
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2019 - 01/2016
2	Heme (Haem)IBA 01/2018 - 08/2012
2	Transcription Factors (Transcription Factor)IBA 01/2018 - 01/2018
2	Protein Isoforms (Isoforms)IBA 01/2018 - 05/2015
2	Cholinesterases (Cholinesterase)IBA 04/2017 - 01/2015
2	Donepezil (Aricept)FDA LinkGeneric 04/2017 - 12/2005
2	GlutamatesIBA 04/2017 - 11/2009
2	ITH14001IBA 01/2017 - 01/2017
2	AminesIBA 02/2015 - 05/2014
2	Free RadicalsIBA 12/2010 - 12/2006
2	salicylhydroxamic acid (SHAM)IBA 02/2009 - 08/2007
2	Memantine (Namenda)FDA Link 02/2009 - 07/2004
1	NADPH Oxidase 4IBA 01/2022
1	NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)IBA 01/2022
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2022
1	Oxidoreductases (Dehydrogenase)IBA 01/2022
1	Purinergic P2X7 ReceptorsIBA 11/2021
1	Messenger RNA (mRNA)IBA 04/2021
1	LipopolysaccharidesIBA 04/2021
1	Deferoxamine (Desferal)FDA LinkGeneric 01/2021
1	IronIBA 01/2021
1	Chelating AgentsIBA 01/2021
1	Protein Kinases (Protein Kinase)IBA 12/2020
1	Therapeutic UsesIBA 12/2020
1	benzothiazoleIBA 12/2020
1	Leucine (L-Leucine)FDA Link 12/2020
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 10/2020
1	ITH12674IBA 01/2020
1	Hydrocortisone (Cortisol)FDA LinkGeneric 11/2019
1	isoquinolineIBA 10/2019
1	AlkaloidsIBA 10/2019
1	Analgesics (Analgesic Drugs)IBA 01/2019
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2019
1	cyclo(prolylglycyl)IBA 01/2019
1	Freund's AdjuvantIBA 01/2019
1	glycyl-prolyl-glutamic acidIBA 01/2019
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2019

Therapy/Procedure

2	Therapeutics 01/2018 - 12/2010